Aminoquinoline derivatives

专利名称：Aminoquinoline derivatives发明人：WERNER HOFHEINZ,CATHERINE

JAQUET,SYNESE JOLIDON

申请号：AU7741994申请日：19941024公开号：AU7741994A公开日：19950518

摘要：The invention relates to aminoquinoline derivatives of the general formula inwhich the symbols R<1> to R<6> are hydrogen or one or two thereof are alkyl and theothers are hydrogen, R<7> and R<8> are alkyl, alkenyl, aralkyl or, together with N,pyrrolidine or piperidine, also substituted by alkyl, octahydroindole or 3-azabicyclo[3.2.2]nonane and n = 0 or 1 or in which the symbols R<1> and R<3> are tri- ortetramethylene, all the other substituents up to R<6> are hydrogen, n = 0 and R<7> andR<8> have the above meanings, or in which the symbols R<1> and R<7> are methyleneor dimethylene and n = 1, R<1> and R<7> are di- or trimethylene and n = 0, R<3> andR<7> are di- or trimethylene and n = 1, R<3> and R<7> are tri- or tetramethylene and n= 0, R<5> and R<7> are tri- or tetramethylene and n = 1, R<1> and R<5> are di- ortrimethylene and n = 1, all the other substituents are hydrogen apart from R<8>, whichis alkyl, alkenyl or aralkyl, or in which the symbols R<3> and R<5> are tri- or

tetramethylene and n = 1, all the other substituents up to R<6> are hydrogen and R<7>and R<8> are alkyl, alkenyl, aralkyl or, together with N, pyrrolidine or piperidine, alsosubstituted by alkyl, R<9> is hydrogen or halogen and R<10> is halogen ortrifluoromethyl, and pharmaceutically acceptable salts of basic compounds of the

general formula I for producing pharmaceuticals for controlling both chloroquine-resistant and chloroquine-sensitive malaria pathogens.

申请人：F.HOFFMANN-LA ROCHE AG

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